A New Spectrophotometric Determination of Famotidine from Tablets

Both the proposed methods were found to be rapid, economical, accurate and precise for the determination of fosinopril sodium in bulk drug and in its tablet dosage form. In results of analysis of marketed tablets by both methods, t-calculated values and F-calculated values were less than the corresponding statistical values, indicating no significant difference in means and variances of results obtained by either of the proposed methods. Both proposed methods produce comparable results and can be used for precise and accurate analysis of fosinopril sodium in its pure and tablet dosage form. Interference studies revealed that the common excipients and other additives usually present in the dosage form did not interfere in both the proposed methods. The values of standard deviation were satisfactory and % recovery was close to 100%, indicating the reproducibility and accuracy of the methods. Any of the proposed methods can be employed as a quality control tool for the analysis of fosinopril sodium in its tablet dosage form and in bulk drug. REFERENCES